Topic: Mechanisms of Pyroptosis in Cardiac Diseases

Pyroptosis, a form of programmed cell death driven by inflammatory signaling pathways, has emerged as a critical mechanism in the pathophysiology of various cardiac diseases, including myocardial infarction, atherosclerosis, and heart failure. This Special Issue delves into the cellular and molecular pathways that govern pyroptosis, particularly the role of inflammasomes and caspase activation in promoting inflammation and cell death within cardiac tissue. By addressing how pyroptosis contributes to cardiac dysfunction and disease progression, as well as exploring potential therapeutic targets to inhibit or modulate this pathway, this issue seeks to provide novel insights into mitigating cardiac injury and improving long-term cardiovascular outcomes.

Topics for this call for papers include but are not restricted to:
1. Role of the NLRP3 Inflammasome in Pyroptosis and Cardiac Injury: Molecular Pathways and Therapeutic Targets;
2. Gasdermin-Mediated Pyroptosis: Implications for Inflammation and Cardiomyocyte Death in Heart Disease;
3. Interplay Between Pyroptosis and Other Forms of Cell Death in Cardiac Ischemia-Reperfusion Injury;
4. Targeting Caspase Activation: Novel Approaches to Modulate Pyroptosis in Heart Failure;
5. Mitochondrial Dysfunction and ROS Production as Triggers for Pyroptosis in Myocardial Cells;
6. Pyroptosis and Cardiometabolic Disease: Bridging Mechanisms Between Inflammation and Cardiac Dysfunction;
7. Emerging Roles of Interleukin-1β and IL-18 in Pyroptosis-Driven Cardiac Fibrosis;
8. The Dual Role of Pyroptosis in Myocardial Infarction: Protective and Pathogenic Mechanisms;
9. Regulation of Gasdermin-D Activation in Cardiac Cells: Pathophysiological Insights and Future Therapies;
10. Therapeutic Potential of Anti-Pyroptotic Agents in Cardiac Disease Management;
11. Deciphering the NOD-like Receptor Signaling Pathways in Pyroptosis-Associated Cardiovascular Diseases;
12. Comparative Analysis of Apoptosis, Necroptosis, and Pyroptosis in Heart Disease Pathogenesis;
13. Role of Inflammatory Cytokines in Pyroptosis-Mediated Myocardial Dysfunction;
14. Epigenetic Modulation of Pyroptosis Pathways in Cardiac Hypertrophy and Heart Failure;
15. Pyroptosis in Diabetic Cardiomyopathy: Linking Metabolic Disturbances to Cardiac Inflammation;
16. Targeting Inflammatory Cell Death in Atherosclerosis: A Focus on Pyroptosis in Cardiovascular Health;
17. The Impact of Viral Infections on Pyroptosis in Cardiomyocytes: Mechanisms and Consequences;
18. Inhibitors of the NLRP3 Inflammasome as Potential Therapies for Pyroptosis-Related Cardiac Conditions;
19. Clinical Relevance of Pyroptosis Biomarkers in Acute and Chronic Cardiac Disease.

31 Mar 2025