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Exploring new therapeutics for Duchenne muscular dystrophy and related cardiomyopathy

Abstract:
Duchenne muscular dystrophy (DMD) is a severe and progressively debilitating X-linked recessive disorder caused by mutations in the DMD gene, which encodes the dystrophin protein. This deficiency in dystrophin results in the... MORE
Open Access Review DOI: 10.20517/rdodj.2024.44 2 Apr 2025
Views: 25 Downloads: 8
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Transcriptomic characterization of Wolbachia endosymbiont from Leuronota fagarae (Hemiptera: Psylloidae)

Abstract:
Aim:Wolbachia species are among the most abundant intracellular endosymbionts of insects worldwide. The extensive distribution of Gram-negative Wolbachia among insects highlights their evolutionary success and close... MORE
Open Access Original Article DOI: 10.20517/mrr.2024.84 2 Apr 2025
Views: 57 Downloads: 3
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Exosomal miR-302b as a novel strategy for reversing cellular senescence and promoting healthy aging

Abstract:
The study by Bi et al. (2025) presents “Senoreverse”, an innovative strategy that utilizes exosomal miR-302b to restore the proliferative capacity of senescent cells (SnCs), thus extending lifespan and enhancing cognitive and... MORE
Open Access Research Highlight DOI: 10.20517/evcna.2025.24 2 Apr 2025
Views: 47 Downloads: 2
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MASLD or MAFLD: fatty liver by any name will pose the same challenge

Open Access Editorial DOI: 10.20517/mtod.2025.18 2 Apr 2025
Views: 38 Downloads: 1
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Metabolism, sex, and what lies beyond the scalpel in MASLD

Abstract:
The discovery of the one-carbon metabolism-homocysteine-metabolic dysfunction-associated steatotic liver disease (OCM-Hcy-MASLD) axis has renewed our understanding of MASLD-related primary liver cancer (PLC). Based on Suzuki et... MORE
Open Access Commentary DOI: 10.20517/mtod.2025.05 2 Apr 2025
Views: 49 Downloads: 4
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Artificial intelligence and image guidance in minimally invasive pancreatic surgery: current status and future challenges

Abstract:
Artificial intelligence (AI), machine learning (ML), and image guidance are increasingly being used to support surgeons in preoperative, intraoperative, and postoperative decision making and optimized patient care. Surgery is the... MORE
Open Access Review DOI: 10.20517/ais.2024.74 1 Apr 2025
Views: 50 Downloads: 6
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Properties and modulation strategies of ZnIn2S4 for photoelectrochemical water splitting: opportunities and prospects

Abstract:
The global energy crisis has driven significant research into renewable energy sources, and photoelectrochemical (PEC) water splitting stands out as one of the most promising solutions for hydrogen production. Among the various materials... MORE
Open Access Review DOI: 10.20517/energymater.2024.158 1 Apr 2025
Views: 103 Downloads: 5
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Automatic assessment of robotic suturing utilizing computer vision in a dry-lab simulation

Abstract:
Aim: Automated surgical skill assessment is poised to become an invaluable asset in surgical residency training. In our study, we aimed to create deep learning (DL) computer vision artificial intelligence (AI) models capable of... MORE
Open Access Original Article DOI: 10.20517/ais.2024.84 31 Mar 2025
Views: 52 Downloads: 23
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Regulatory T cell-based therapies for type 1 diabetes: a narrative review

Abstract:
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of pancreatic insulin-secreting beta cells, resulting in hyperglycemia and a lifelong need for exogenous insulin therapy. Regulatory T cells (Tregs) are essential for... MORE
Open Access Review DOI: 10.20517/mtod.2024.52 31 Mar 2025
Views: 95 Downloads: 10
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Age-related hearing loss: the complex interaction of carbohydrate metabolism in auditory and cognitive dysfunction during aging

Abstract:
Age-related hearing loss (ARHL) is an extremely widespread form of age-related disease mainly characterized by high-frequency hearing loss and subsequent cognitive dysfunction. The pathological changes associated with ARHL involve both... MORE
Open Access Review DOI: 10.20517/and.2024.35 31 Mar 2025
Views: 33 Downloads: 5
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Monitoring and treatment of alcohol use disorder: an integrated multidisciplinary model

Abstract:
Alcohol-associated liver disease (ALD) is one of the most prevalent liver diseases and a leading indication for liver transplantation (LT). Alcohol use disorder (AUD), commonly present in patients with ALD, may also be associated with... MORE
Open Access Review DOI: 10.20517/mtod.2024.103 30 Mar 2025
Views: 61 Downloads: 11
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Advances and advantages of metal-organic framework and its composite membrane as proton conduction materials

Abstract:
The proton exchange membrane (PEM) fuel cell (FC) represents a new and efficient form of clean energy, offering unique advantages such as high power density and long service life. It is considered to be a promising new generation... MORE
Open Access Review DOI: 10.20517/microstructures.2024.84 30 Mar 2025
Views: 153 Downloads: 28
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Circular RNAs modulate cancer drug resistance: advances and challenges

Abstract:
Acquired drug resistance is a main factor contributing to cancer therapy failure and high cancer mortality, highlighting the necessity to develop novel intervention targets. Circular RNAs (circRNAs), an abundant class of RNA molecules with... MORE
Open Access Review DOI: 10.20517/cdr.2024.195 27 Mar 2025
Views: 74 Downloads: 42
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Symbolic regression accelerates the discovery of quantitative relationships in rubber material aging

Abstract:
Polymer materials, especially rubber, play an indispensable role in modern life and manufacturing. However, their aging and deterioration pose serious challenges to their stability and service life. Unexpected aging can lead to the... MORE
Open Access Research Article DOI: 10.20517/jmi.2024.103 27 Mar 2025
Views: 178 Downloads: 73
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Uncertainty aware design space modeling for sample efficiency in material design of bainitic steels

Abstract:
Optimizing sampling efficiency is crucial for solving complex material design challenges, especially with a limited experimental budget. This study focuses on improving sampling efficiency by reducing the search space for carbide-free... MORE
Open Access Research Article DOI: 10.20517/jmi.2024.90 27 Mar 2025
Views: 109 Downloads: 47
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Exosomal miR-92b-5p regulates N4BP1 to enhance PTEN mono-ubiquitination in doxorubicin-resistant AML

Abstract:
Aim: Doxorubicin, pivotal for acute myeloid leukemia (AML) treatment, often succumbs to resistance, impeding therapeutic success. Although exosomal transfer is linked to chemoresistance, the detailed role of exosomal miRNAs in... MORE
Open Access Original Article DOI: 10.20517/cdr.2024.140 27 Mar 2025
Views: 72 Downloads: 87
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Dual-channel event-triggered consensus of multi-agent systems under DoS attacks over switching topologies

Abstract:
In this paper, a dual-channel event-triggered control (ETC) protocol with a state estimator is designed in multi-agent systems with switching topologies under denial-of-service attacks. Firstly, an ETC protocol and a dynamic ETC protocol... MORE
Open Access Research Article DOI: 10.20517/ces.2024.104 27 Mar 2025
Views: 87 Downloads: 56
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The ion-ion correlations in organic ionic plastic crystal

Abstract:
Organic ionic plastic crystals (OIPCs) are emerging as promising electrolyte materials for solid-state batteries. However, despite the fast ionic diffusion, OIPCs exhibit relatively low DC conductivity in solid phases caused by strong... MORE
Open Access Article DOI: 10.20517/energymater.2024.209 27 Mar 2025
Views: 120 Downloads: 58
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Zwitterionic gemini additive as interface engineers for long-life aqueous Zn/TEMPO flow batteries with enhanced areal capacity

Abstract:
Aqueous Zn-based flow batteries often face issues such as poor reversibility and short lifespan due to irregular Zn deposition and detrimental side reactions. To address these challenges, we developed a zwitterionic gemini additive,... MORE
Open Access Article DOI: 10.20517/energymater.2024.161 27 Mar 2025
Views: 367 Downloads: 37
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Dual etiology vs. MetALD: how MAFLD and MASLD address liver diseases coexistence

Abstract:
Fatty liver disease associated with metabolic dysfunction has emerged as a significant global health challenge. This condition often coexists with other liver diseases, such as alcohol-related liver disease and viral hepatitis,... MORE
Open Access Review DOI: 10.20517/mtod.2025.04 27 Mar 2025
Views: 86 Downloads: 16
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