fig1

Figure 1. E. lenta colonised the caecum of OMM12 mice. (A) Beta-diversity analysis of colonisation groups shown as a multi-dimensional scaling plot of generalised UniFrac distances (P = 0.001; PERMANOVA); (B) Same as in panel (A), visualised per colonisation/diet groups (P = 0.001; PERMANOVA); (C) Bacterial composition in caecum of gnotobiotic mice (16S rRNA gene amplicon sequencing). Data plotted as dots representing individual mice; black bars indicate median values. B. animalis and A. muris were not detected. Statistics: strains detected in > 50% of the mice in at least one diet group were compared statistically using Mann-Whitney tests with Benjamini-Hochberg adjustment. Stars indicate significant differences between colonisation groups (*adj. P < 0.05; **adj. P < 0.01; including correction within each diet group; n = 11 tests). Different letters indicate significant differences between the corresponding diets for each strain (correction of P-values for each strain individually; n = 12 tests). A previous version of this figure was published in the PhD thesis by co-author Theresa Streidl^[58]. OMM12: Oligo-Mouse Microbiota; MM: mice colonised with the mouse synthetic community OMM12; E.L: mice colonised with OMM12 and Coriobacteriia; CD: control diet; CD-BA: control diet supplemented with 0.2% primary bile acids; HFD: lard-based high-fat diet; HFD-BA: HFD supplemented with 0.2% primary bile acids.