fig4

Figure 4. LEfSe analysis of the salivary microbiota data showed five genera associated with no-CB and one for CB (A). B. fragilis in the gut is associated with CB. LEfSe analysis (B) showed that B. fragilis is associated with CB. Box plots (C) further showed that patients with CB consistently had a greater relative abundance of B. fragilis than no-CB. This observation was most significant at EoT [Mann Whitney U: P = 0.009, U = 0, median (yes, no) = 1.95, 0.38, range (0.00-11.73)]. LEfSe: Linear discriminant analysis effect size; CB: clinical benefit.