fig4

Figure 4. GMMs and predicted metabolites in PD and PD-CI. (A) Distribution of different GMMs in significantly differential SGBs identified between PD and PD-CI groups; (B) Differences in predicted metabolites, compared by Wilcoxon test. The corresponding P values are reported. The circles in the bubble plot indicate the inclusion of that module. PD: PD patients with normal cognition; PD-CI: PD patients with cognitive impairment. RPKM: reads per kilobase per million mapped reads; GMMs: gut metabolic modules; SGBs: species-level genomic bins.