fig4

Figure 4. Pediococcus acidilactici CCFM6432’s effect on the fecal metabolome. (A) Differences in gut microbiota metabolites before and after intervention in the CCFM6432 group. Fold change > 2 and P 2 and P < 0.05 were set as the thresholds for biomarker screening; (C) Absolute quantification of DL-lactic acid. ^**P < 0.01 in paired t-test. ^##P < 0.01 in the unpaired t-tests; (D) Correlation analysis between changes in scale scores and changes in gut metabolites before and after intervention. The correlation was established by DSPC network. The size of each node is proportional to the number of connections. Red lines represent a positive correlation, and blue lines represent a negative correlation. The width of the line represents the correlation strength. DSPC: Debiased sparse partial correlation.