fig4

Figure 4. Follow-up of bacterial species known to be involved in the PAC metabolism. Evolution of bacteria species potentially involved in PAC metabolism during the TWIN-M-SHIME® fermentation for the six donors. Deseq2 analysis was performed separately in the lumen of the (A) ascending and (B) transverse colon and in the mucus of the (C) ascending and (D) transverse colon. Statistical differences between the control and cranberry extract supplementation across gut regions were determined using a Wald Test with Benjamini-Hochberg multiple testing correction. Only species with statistical differences (α = 0.05) between the control and the second week of treatment are presented. PAC: Proanthocyanidins.