fig2

Figure 2. The supplementation with a cranberry extract exhibits distinct effects on microbiotas across different colon regions. Volcano plots displaying the significantly enriched genera after supplementation as determined using a Wald test with Benjamini-Hochberg multiple testing correction in the lumen (A) and mucus (C) of the ascending colon and the lumen (B) and mucus (D) of the transverse colon, respectively. Deseq2 analysis of log2 fold-changes displays on the left of the x-axis (in blue) the genera depleted after the two weeks of supplementation, while on the right (in red), the ones enriched after the two weeks of supplementation. The y-axis shows the log-transformed adjusted P-value with the dashed line indicating the α = 0.05 significance threshold. Statistical differences between the control and the second week of supplementation were determined using a Wald Test with Benjamini-Hochberg multiple correction test.