fig4

Figure 4. The association between Akkermansia and improved survival following PD-1 blockade treatment depends on the dominant Akkermansia species and sub-phylogroup. (A) A Cox regression model was used to determine the factors associated with prolonged survival after treatment for non-small-cell lung cancer. Cumulative survival is displayed using dominant Akkermansia species as the predictive variable, colored by species. The line for A. massiliensis is dotted to make the line for Akkermansia-negative samples visible; (B) The tabular results of the Cox regression model reveal that the relationship between Akkermansia and prolonged survival is specific to A. muciniphila (AmI); (C) A Cox regression model was used to determine the factors associated with prolonged survival after treatment for non-small-cell lung cancer. Cumulative survival is displayed using the dominant A. muciniphila phylogroup as the predictive variable; (D) The tabular results of the Cox regression model reveal that the relationship between A. muciniphila and prolonged survival is specific to the AmIa phylogroup.