fig2

Figure 2. Beta diversity metrics at ASV level. Comparison of (A) unweighted and (B) weighted UniFrac between FAP-NOS (orange triangle) and control groups (blue circle); Visualization of effect of (C) country, (D) fecal dry weight, (E) enterotype, and (F) fecal pH on unweighted UniFrac; Visualization of effect of (G) enterotype, (H) bacterial load, and (I) fecal pH on weighted UniFrac. Small symbols display individual microbiota, large symbols display centroids, and ellipses indicate 95% confidence intervals. All significances were calculated using a linear model fitted to various distance metrics [Supplementary Tables 5 and 6]. FAP-NOS: Functional abdominal pain-not otherwise specified; E1: enterotype 1; E2: enterotype 2; ASV: amplicon sequence variant.