fig1

Figure 1. Development of OA according to Lpps administration. Representative images of macroscopic degradation. (A) and of H&E- stained joints; (B) of left knee (no injection), right MIA-injected joint from untreated and Lpps treated rat; (C) significant lower prevalence of OA in Lpps treated group (Fisher’s exact test; P < 0.008); (D) rat discrimination by bacteria profiling according to OA using PSL-R analysis. BC: treated rats; W: water-drinking rats; dark circle: OA rats; grey circle: healthy rats.