REFERENCES
1. Stout MJ, Wylie TN, Gula H, Miller A, Wylie KM. The microbiome of the human female reproductive tract. Current Opinion in Physiology 2020;13:87-93.
2. Kho ZY, Lal SK. The human gut microbiome - a potential controller of wellness and disease. Front Microbiol 2018;9:1835.
3. Koedooder R, Mackens S, Budding A, et al. Identification and evaluation of the microbiome in the female and male reproductive tracts. Hum Reprod Update 2019;25:298-325.
4. Chen X, Lu Y, Chen T, Li R. The female vaginal microbiome in health and bacterial vaginosis. Front Cell Infect Microbiol 2021;11:631972.
5. France M, Alizadeh M, Brown S, Ma B, Ravel J. Towards a deeper understanding of the vaginal microbiota. Nat Microbiol 2022;7:367-78.
6. Petrova MI, Lievens E, Malik S, Imholz N, Lebeer S. Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol 2015;6:81.
7. Delgado-Diaz DJ, Tyssen D, Hayward JA, Gugasyan R, Hearps AC, Tachedjian G. Distinct immune responses elicited from cervicovaginal epithelial cells by lactic acid and short chain fatty acids associated with optimal and non-optimal vaginal microbiota. Front Cell Infect Microbiol 2019;9:446.
8. Kaambo E, Africa C, Chambuso R, Passmore JS. Vaginal microbiomes associated with aerobic vaginitis and bacterial vaginosis. Front Public Health 2018;6:78.
10. Petrova MI, Reid G, Vaneechoutte M, Lebeer S. Lactobacillus iners: friend or foe? Trends Microbiol 2017;25:182-91.
11. Johnson B, Selle K, O’Flaherty S, Goh YJ, Klaenhammer T. Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM. Microbiology (Reading) 2013;159:2269-82.
12. Vagios S, Mitchell CM. Mutual preservation: a review of interactions between cervicovaginal mucus and microbiota. Front Cell Infect Microbiol 2021;11:676114.
13. Gliniewicz K, Schneider GM, Ridenhour BJ, et al. Comparison of the vaginal microbiomes of premenopausal and postmenopausal women. Front Microbiol 2019;10:193.
14. Amabebe E, Anumba DOC. The vaginal microenvironment: the physiologic role of Lactobacilli. Front Med (Lausanne) 2018;5:181.
15. Witkin SS, Linhares IM. Why do Lactobacilli dominate the human vaginal microbiota? BJOG 2017;124:606-11.
17. Tytgat HLP, de Vos WM. Sugar coating the envelope: glycoconjugates for microbe-host crosstalk. Trends Microbiol 2016;24:853-61.
18. Pereira MS, Alves I, Vicente M, et al. Glycans as key checkpoints of T cell activity and function. Front Immunol 2018;9:2754.
19. Clark GF, Schust DJ. Manifestations of immune tolerance in the human female reproductive tract. Front Immunol 2013;4:26.
20. Rabinovich GA, Toscano MA. Turning ‘sweet’ on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 2009;9:338-52.
21. Johnson BR, Hymes J, Sanozky-Dawes R, Henriksen ED, Barrangou R, Klaenhammer TR. Conserved S-layer-associated proteins revealed by exoproteomic survey of S-layer-forming Lactobacilli. Appl Environ Microbiol 2016;82:134-45.
22. Hymes JP, Klaenhammer TR. Stuck in the middle: fibronectin-binding proteins in gram-positive bacteria. Front Microbiol 2016;7:1504.
23. Lin B, Qing X, Liao J, Zhuo K. Role of protein glycosylation in host-pathogen interaction. Cells 2020;9:1022.
24. Konstantinov SR, Smidt H, de Vos WM, et al. S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions. Proc Natl Acad Sci U S A 2008;105:19474-9.
25. Lightfoot YL, Selle K, Yang T, et al. SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO J 2015;34:881-95.
26. Acosta M, Geoghegan EM, Lepenies B, Ruzal S, Kielian M, Martinez MG. Surface (S) layer proteins of Lactobacillus acidophilus block virus infection via DC-SIGN interaction. Front Microbiol 2019;10:810.
27. Klotz C, Goh YJ, O'Flaherty S, Barrangou R. S-layer associated proteins contribute to the adhesive and immunomodulatory properties of Lactobacillus acidophilus NCFM. BMC Microbiol 2020;20:248.
28. Hymes JP, Johnson BR, Barrangou R, Klaenhammer TR. Functional analysis of an S-layer-associated fibronectin-binding protein in Lactobacillus acidophilus NCFM. Appl Environ Microbiol 2016;82:2676-85.
29. Johnson BR, Klaenhammer TR. AcmB is an S-layer-associated β-N-acetylglucosaminidase and functional autolysin in Lactobacillus acidophilus NCFM. Appl Environ Microbiol 2016;82:5687-97.
31. Karamanos NK, Theocharis AD, Piperigkou Z, et al. A guide to the composition and functions of the extracellular matrix. FEBS J 2021;288:6850-912.
32. Antikainen J, Anton L, Sillanpää J, Korhonen TK. Domains in the S-layer protein CbsA of Lactobacillus crispatus involved in adherence to collagens, laminin and lipoteichoic acids and in self-assembly. Mol Microbiol 2002;46:381-94.
33. Sillanpää J, Martínez B, Antikainen J, et al. Characterization of the collagen-binding S-layer protein CbsA of Lactobacillus crispatus. J Bacteriol 2000;182:6440-50.
34. Sun Z, Kong J, Hu S, Kong W, Lu W, Liu W. Characterization of a S-layer protein from Lactobacillus crispatus K313 and the domains responsible for binding to cell wall and adherence to collagen. Appl Microbiol Biotechnol 2013;97:1941-52.
35. Abramov V, Khlebnikov V, Kosarev I, et al. Probiotic properties of Lactobacillus crispatus 2029: homeostatic interaction with cervicovaginal epithelial cells and antagonistic activity to genitourinary pathogens. Probiotics Antimicrob Proteins 2014;6:165-76.
36. Abramov VM, Kosarev IV, Priputnevich TV, et al. S-layer protein 2 of Lactobacillus crispatus 2029, its structural and immunomodulatory characteristics and roles in protective potential of the whole bacteria against foodborne pathogens. Int J Biol Macromol 2020;150:400-12.
37. Pan M, Hidalgo-Cantabrana C, Barrangou R. Host and body site-specific adaptation of Lactobacillus crispatus genomes. NAR Genom Bioinform 2020;2:lqaa001.
38. Tytgat HL, Lebeer S. The sweet tooth of bacteria: common themes in bacterial glycoconjugates. Microbiol Mol Biol Rev 2014;78:372-417.
39. McKitrick TR, Ackerman ME, Anthony RM, et al. The crossroads of glycoscience, infection, and immunology. Front Microbiol 2021;12:731008.
40. Hynönen U, Palva A. Lactobacillus surface layer proteins: structure, function and applications. Appl Microbiol Biotechnol 2013;97:5225-43.
41. Fina Martin J, Palomino MM, Cutine AM, et al. Exploring lectin-like activity of the S-layer protein of Lactobacillus acidophilus ATCC 4356. Appl Microbiol Biotechnol 2019;103:4839-57.
42. Varki A, Gagneux P. Biological functions of glycans. In: Varki A, Cummings RD, Esko JD, et al., editors. Essentials of glycobiology [Internet]. 3rd ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 7.
43. Schauer R. Sialic acids as regulators of molecular and cellular interactions. Curr Opin Struct Biol 2009;19:507-14.
46. Lübbers J, Rodríguez E, van Kooyk Y. Modulation of immune tolerance via siglec-sialic acid interactions. Front Immunol 2018;9:2807.
47. Cummings RD, Schnaar RL, Esko JD, Drickamer K, Taylor ME. Principles of glycan recognition. In: Varki A, Cummings RD, Esko JD, et al., editors. Essentials of glycobiology [Internet]. 3rd ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 29.
48. Mariano VS, Zorzetto-Fernandes AL, da Silva TA, et al. Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity. PLoS One 2014;9:e98512.
49. Simpson DJ, Sacher JC, Szymanski CM. Exploring the interactions between bacteriophage-encoded glycan binding proteins and carbohydrates. Curr Opin Struct Biol 2015;34:69-77.
50. Bousfield GR, May JV, Davis JS, Dias JA, Kumar TR. In vivo and in vitro impact of carbohydrate variation on human follicle-stimulating hormone function. Front Endocrinol (Lausanne) 2018;9:216.
51. Campo S, Andreone L, Ambao V, Urrutia M, Calandra RS, Rulli SB. Hormonal regulation of follicle-stimulating hormone glycosylation in males. Front Endocrinol (Lausanne) 2019;10:17.
52. Willey KP. An elusive role for glycosylation in the structure and function of reproductive hormones. Hum Reprod Update 1999;5:330-55.
53. Rabinovich GA, van Kooyk Y, Cobb BA. Glycobiology of immune responses. Ann N Y Acad Sci 2012;1253:1-15.
54. Moncla BJ, Chappell CA, Mahal LK, Debo BM, Meyn LA, Hillier SL. Impact of bacterial vaginosis, as assessed by nugent criteria and hormonal status on glycosidases and lectin binding in cervicovaginal lavage samples. PLoS One 2015;10:e0127091.
55. Mahlapuu M, Håkansson J, Ringstad L, Björn C. Antimicrobial peptides: an emerging category of therapeutic agents. Front Cell Infect Microbiol 2016;6:194.
56. Yarbrough VL, Winkle S, Herbst-Kralovetz MM. Antimicrobial peptides in the female reproductive tract: a critical component of the mucosal immune barrier with physiological and clinical implications. Hum Reprod Update 2015;21:353-77.
57. Lewis AL, Lewis WG. Host sialoglycans and bacterial sialidases: a mucosal perspective. Cell Microbiol 2012;14:1174-82.
58. Moncla BJ, Chappell CA, Debo BM, Meyn LA. The effects of hormones and vaginal microflora on the glycome of the female genital tract: cervical-vaginal fluid. PLoS One 2016;11:e0158687.
59. Morrill S, Gilbert NM, Lewis AL. Gardnerella vaginalis as a cause of bacterial vaginosis: appraisal of the evidence from in vivo models. Front Cell Infect Microbiol 2020;10:168.
60. Hardy L, Cerca N, Jespers V, Vaneechoutte M, Crucitti T. Bacterial biofilms in the vagina. Res Microbiol 2017;168:865-74.
61. Castro J, Machado D, Cerca N. Unveiling the role of Gardnerella vaginalis in polymicrobial bacterial vaginosis biofilms: the impact of other vaginal pathogens living as neighbors. ISME J 2019;13:1306-17.
62. Lewis WG, Robinson LS, Gilbert NM, Perry JC, Lewis AL. Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. J Biol Chem 2013;288:12067-79.
63. Smith SB, Ravel J. The vaginal microbiota, host defence and reproductive physiology. J Physiol 2017;595:451-63.
64. Hoang T, Toler E, DeLong K, et al. The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis. PLoS Pathog 2020;16:e1008236.
65. France MT, Fu L, Rutt L, et al. Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data. Genome Biol 2022;23:66.
66. France MT, Rutt L, Narina S, et al. Complete genome sequences of six Lactobacillus iners strains isolated from the human vagina. Microbiol Resour Announc 2020;9:e00234-20.
67. Varki A, Schnaar RL, Schauer R. Sialic acids and other nonulosonic acids. In: Varki A, Cummings RD, Esko JD, et al., editors. Essentials of glycobiology [Internet]. 3rd ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 15.
68. Varki NM, Varki A. Diversity in cell surface sialic acid presentations: implications for biology and disease. Lab Invest 2007;87:851-7.
69. Raposo CD, Canelas AB, Barros MT. Human lectins, their carbohydrate affinities and where to find them. Biomolecules 2021;11:188.
70. Koppolu S, Wang L, Mathur A, et al. Vaginal product formulation alters the innate antiviral activity and glycome of cervicovaginal fluids with implications for viral susceptibility. ACS Infect Dis 2018;4:1613-22.
71. Sun Z, Harris HM, McCann A, et al. Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera. Nat Commun 2015;6:8322.
72. Zhou X, Yang B, Stanton C, et al. Comparative analysis of Lactobacillus gasseri from Chinese subjects reveals a new species-level taxa. BMC Genomics 2020;21:119.
73. Lee S, You HJ, Kwon B, Ko G. Complete genome sequence of Lactobacillus jensenii strain SNUV360, a probiotic for treatment of bacterial vaginosis isolated from the vagina of a healthy Korean woman. Genome Announc 2017;5:e01757-16.
74. Bonnardel F, Haslam SM, Dell A, et al. Proteome-wide prediction of bacterial carbohydrate-binding proteins as a tool for understanding commensal and pathogen colonisation of the vaginal microbiome. NPJ Biofilms Microbiomes 2021;7:49.
75. Espino E, Koskenniemi K, Mato-Rodriguez L, et al. Uncovering surface-exposed antigens of Lactobacillus rhamnosus by cell shaving proteomics and two-dimensional immunoblotting. J Proteome Res 2015;14:1010-24.
76. Campanero-Rhodes MA, Palma AS, Menéndez M, Solís D. Microarray strategies for exploring bacterial surface glycans and their interactions with glycan-binding proteins. Front Microbiol 2019;10:2909.
78. Oliveira de Almeida M, Carvalho R, Figueira Aburjaile F, et al. Characterization of the first vaginal Lactobacillus crispatus genomes isolated in Brazil. PeerJ 2021;9:e11079.
79. van der Veer C, Hertzberger RY, Bruisten SM, et al. Comparative genomics of human Lactobacillus crispatus isolates reveals genes for glycosylation and glycogen degradation: implications for in vivo dominance of the vaginal microbiota. Microbiome 2019;7:49.
80. Mendes-Soares H, Suzuki H, Hickey RJ, Forney LJ. Comparative functional genomics of Lactobacillus spp. reveals possible mechanisms for specialization of vaginal lactobacilli to their environment. J Bacteriol 2014;196:1458-70.
81. Tyagi T, Alarab M, Leong Y, Lye S, Shynlova O. Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse. J Cell Mol Med 2019;23:2907-19.
82. Bradford LL, Ravel J. The vaginal mycobiome: a contemporary perspective on fungi in women’s health and diseases. Virulence 2017;8:342-51.
83. Puebla-Barragan S, Watson E, van der Veer C, et al. Interstrain variability of human vaginal Lactobacillus crispatus for metabolism of biogenic amines and antimicrobial activity against urogenital pathogens. Molecules 2021;26:4538.
84. Gabriel IM, Vitonis AF, Welch WR, Titus L, Cramer DW. Douching, talc use, and risk for ovarian cancer and conditions related to genital tract inflammation. Cancer Epidemiol Biomarkers Prev 2019;28:1835-44.
85. Dunbar B, Patel M, Fahey J, Wira C. Endocrine control of mucosal immunity in the female reproductive tract: impact of environmental disruptors. Mol Cell Endocrinol 2012;354:85-93.
86. Mancini V, Pensabene V. Organs-on-chip models of the female reproductive system. Bioengineering (Basel) 2019;6:103.
87. Hearps AC, Tyssen D, Srbinovski D, et al. Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition. Mucosal Immunol 2017;10:1480-90.
88. Chaichian S, Moazzami B, Sadoughi F, Haddad Kashani H, Zaroudi M, Asemi Z. Functional activities of beta-glucans in the prevention or treatment of cervical cancer. J Ovarian Res 2020;13:24.
89. Ferreira IG, Pucci M, Venturi G, Malagolini N, Chiricolo M, Dall’Olio F. Glycosylation as a main regulator of growth and death factor receptors signaling. Int J Mol Sci 2018;19:580.
90. Zhou JZ, Way SS, Chen K. Immunology of uterine and vaginal mucosae: (trends in immunology 39, 302-314, 2018). Trends Immunol 2018;39:355.
