fig15
From: Mechanoimmunomodulation-based strategy on advancing tissue-engineered nanotopographic structures
Figure 15. A schematic diagram shows the development of nanotopographic structures based on mechanoimmunomodulation. To fabricate nanotopographic structures that induce the desired immune response in specific cells, the candidate mechanosensitive membrane proteins should be first identified, followed by unveiling their activation mechanisms and downstream effects. Subsequently, based on the requirements, such as the magnitude and direction of the mechanical forces required for the target mechanosensitive membrane proteins to elicit the desired immune response, the ideal nanotopographic structures can be rationally designed by adjusting or combining different parameters, including shape, height, width, and spacing.
