fig12

Figure 12. NF-κB signaling and the ultimate macrophage inflammatory responses are alleviated in the nanorod and nanohemisphere groups. (A-C) GSEA results of the NF-κB signaling pathway, representative immunofluorescent staining images of p65 nuclear translocation and it’s semi-quantitative statistical analysis result; (D-F) GSEA results of the inflammatory response and the expression heatmap of leading genes across different surfaces; (G-I) RT-qPCR results of several typical inflammatory genes, representative immunofluorescent staining images and semi-quantitative statistical analysis of the expression of CD86 across different surfaces. Significant differences between two groups are defined by P < 0.05 and presented as follows: ^avs. Flat, ^bvs. NHS, ^cvs. NR, and ^dvs. NHO. All data are means ± SD; n ≥ 3. This figure is quoted with permission from Guo et al.^[24].