fig1

The uniqueness of ABCB5 as a full transporter ABCB5FL and a half-transporter-like ABCB5β

Figure 1. Topology of ABCB5FL and ABCB5β. Two-dimensional representation of the topology of ABCB5FL and ABCB5β based on CCTOP prediction[9]. ABCB5FL is composed of 12 TMH (shown in blue) and two NBD (shown in orange). The NBDs are composed of an A-Loop, Walker A, Q-Loop, signature motif, Walker B, D-Loop, and H-Loop; the amino acid sequences are detailed in the corresponding boxes. ABCB5β consists of 6 TMHs and two NBDs. The N-terminal NBD lacks the A-Loop and the Walker A motif. CCTOP: Consensus Constrained TOPology prediction; TMH: transmembrane helice; NBD: nucleotide-binding domain.

Cancer Drug Resistance
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