fig1

Figure 1. Topology of ABCB5FL and ABCB5β. Two-dimensional representation of the topology of ABCB5FL and ABCB5β based on CCTOP prediction^[9]. ABCB5FL is composed of 12 TMH (shown in blue) and two NBD (shown in orange). The NBDs are composed of an A-Loop, Walker A, Q-Loop, signature motif, Walker B, D-Loop, and H-Loop; the amino acid sequences are detailed in the corresponding boxes. ABCB5β consists of 6 TMHs and two NBDs. The N-terminal NBD lacks the A-Loop and the Walker A motif. CCTOP: Consensus Constrained TOPology prediction; TMH: transmembrane helice; NBD: nucleotide-binding domain.