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CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway
Open Access Original Article 25 Sep 2025
DOI: 10.20517/cdr.2025.38
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Cisplatin resistance in head and neck squamous cell carcinoma is linked to DNA damage response and cell cycle arrest transcriptomics rather than poor drug uptake
Open Access Original Article 18 Sep 2025
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Molecular targeting of the deubiquitinase USP14 to circumvent cisplatin resistance in ovarian carcinoma and identification of novel inhibitors
Open Access Original Article 17 Sep 2025
DOI: 10.20517/cdr.2025.88
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Distinct adaptive strategies to cisplatin, vinblastine and gemcitabine in a panel of chemoresistant bladder cancer cell lines
Open Access Original Article 11 Sep 2025
DOI: 10.20517/cdr.2025.95
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Immune checkpoint inhibitors in hepatocellular carcinoma therapy: resistance mechanisms, liver transplantation challenges and management strategies
Open Access Review 10 Sep 2025
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Integrating genomic mutations and tumor-infiltrating lymphocytes improves prediction of response to trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer
Open Access Original Article 7 Sep 2025
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Targeting the hypoxia signaling pathway with nanomedicine to reverse immunotherapy resistance
Open Access Review 1 Sep 2025
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Cryptotanshinone differentially induces cell death in ATP6V0D1-deficient pancreatic cancer cells
Open Access Original Article 26 Aug 2025
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Resistance signatures manifested in early drug response across cancer types and species
Open Access Original Article 25 Aug 2025
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New advances in understanding the mechanisms and treatment challenges of ALK-targeted therapy resistance in lung cancer
Open Access Review 24 Aug 2025
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ROS1 mutations promote an immunosuppressive tumor microenvironment via MYC to confer immune evasion in head and neck cancer
Open Access Original Article 21 Aug 2025
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IRE1α modulates M1 oncolytic virus sensitivity via ER stress regulation in bladder cancer
Open Access Original Article 12 Aug 2025
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Corosolic acid increases the therapeutic effect of cisplatin on gastric cancer by regulating Gpx4-dependent ferroptosis
Open Access Original Article 6 Aug 2025
DOI: 10.20517/cdr.2025.94
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Lactylation: a novel driver of drug resistance in the tumor microenvironment
Open Access Review 3 Aug 2025
DOI: 10.20517/cdr.2025.90
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Effects of FAP+ cancer-associated fibroblasts on anti-PD-1 immunotherapy and CD4+ T cell polarization in gastric cancer
Open Access Original Article 28 Jul 2025
DOI: 10.20517/cdr.2025.97
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Super-enhancer inhibitors THZ2 and JQ1 reverse temozolomide resistance in glioblastoma by suppressing SE-driven SOX9 expression
Open Access Original Article 21 Jul 2025
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Decoding breast cancer treatment resistance through genetic, epigenetic, and immune-regulatory mechanisms: from molecular insights to translational perspectives
Open Access Review 20 Jul 2025
DOI: 10.20517/cdr.2025.69
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CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axis
Open Access Original Article 14 Jul 2025
DOI: 10.20517/cdr.2025.76
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