fig1

Figure 1. Melatonin improves the autonomous behavior and cognitive ability of P301S mice. (A) The experimental flow chart; (B) Melatonin content in the brain of WT mice. n = 3; (C and D) The escape latency and path length of melatonin-treated P301S mice were reduced in the hidden platform tests of the MWM; (E) The passage times of P301S mice were increased by melatonin treatment; (F) Total movement distance of P301S mice in open field exploration; (G) The time of activity was increased in the center of the open field during OFT; (H) The movement tracks of P301S mice were shown in OFT; (I) The ability to construct nests of P301S mice was ameliorated by melatonin treatment. Data represent the mean ± SEM (n = 8). ^*P < 0.05. WT: Wild-type; MWM: Morris water maze; OFT: open field test; SEM: standard error of the mean.