fig6

Figure 6. MUC1-C dictates JUN and BAF-mediated chromatin remodeling at a proximal enhancer-like signature (pELS) in the NOTCH1 gene. MUC1-C interacts directly with JUN to form a complex that occupies a pELS in the NOTCH1 gene. In turn, MUC1-C-JUN complexes recruit BAF, as evidenced by MUC1-C-dependent occupancy of both JUN and ARID1A. MUC1-C is necessary for increasing (i) chromatin accessibility, and (ii) H3K27ac and H3K4me3 marks at the pELS in association with the activation of NOTCH1 expression. Modified from Bhattacharya^[57].