REFERENCES
1. Niec RE, Rudensky AY, Fuchs E. Inflammatory adaptation in barrier tissues. Cell 2021;184:3361-75.
2. Ge Y, Gomez NC, Adam RC, et al. Stem cell lineage infidelity drives wound repair and cancer. Cell 2017;169:636-650.e14.
3. Kufe D, Inghirami G, Abe M, et al. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 1984;3:223-32.
4. Duraisamy S, Kufe T, Ramasamy S, Kufe D. Evolution of the human MUC1 oncoprotein. Int J Oncol 2007;31:671-7.
6. Kufe DW. MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment. Carcinogenesis 2020;41:1173-83.
7. Pelaseyed T, Zäch M, Petersson AC, et al. Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device. FEBS J 2013;280:1491-501.
8. Shurer CR, Kuo JC, Roberts LM, et al. Physical principles of membrane shape regulation by the glycocalyx. Cell 2019;177:1757-1770.e21.
9. Rajabi H, Alam M, Takahashi H, et al. MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene 2014;33:1680-9.
10. Altschuler Y, Kinlough CL, Poland PA, et al. Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state. Mol Biol Cell 2000;11:819-31.
11. Leng Y, Cao C, Ren J, et al. Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62. J Biol Chem 2007;282:19321-30.
12. Panchamoorthy G, Jin C, Raina D, et al. Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate. JCI Insight 2018;3:99880.
13. Li W, Zhang N, Jin C, et al. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight 2020;5:137112.
14. Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986;315:1650-9.
15. Yasumizu Y, Rajabi H, Jin C, et al. MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Nat Commun 2020;11:338.
16. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72.
17. Takahashi K, Yamanaka S. A decade of transcription factor-mediated reprogramming to pluripotency. Nat Rev Mol Cell Biol 2016;17:183-93.
18. Ben-Porath I, Thomson MW, Carey VJ, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499-507.
19. Riggs JW, Barrilleaux BL, Varlakhanova N, et al. Induced pluripotency and oncogenic transformation are related processes. Stem Cells Dev 2013;22:37-50.
20. Iglesias JM, Gumuzio J, Martin AG. Linking pluripotency reprogramming and cancer. Stem Cells Transl Med 2017;6:335-9.
21. Wollenzien H, Voigt E, Kareta MS. Somatic pluripotent genes in tissue repair, developmental disease, and cancer. SPG Biomed 2018:1.
22. Raina D, Ahmad R, Rajabi H, et al. Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells. Int J Oncol 2012;40:1643-9.
23. Rajabi H, Kufe D. MUC1-C oncoprotein integrates a program of EMT, epigenetic reprogramming and immune evasion in human carcinomas. Biochim Biophys Acta Rev Cancer 2017;1868:117-22.
24. Rajabi H, Hiraki M, Kufe D. MUC1-C activates polycomb repressive complexes and downregulates tumor suppressor genes in human cancer cells. Oncogene 2018;37:2079-88.
25. Schäfer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol 2008;9:628-38.
26. Arwert EN, Hoste E, Watt FM. Epithelial stem cells, wound healing and cancer. Nat Rev Cancer 2012;12:170-80.
27. Ge Y, Fuchs E. Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer. Nat Rev Genet 2018;19:311-25.
28. Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med 2019;25:1822-32.
29. Greten FR, Grivennikov SI. Inflammation and cancer: triggers, mechanisms, and consequences. Immunity 2019;51:27-41.
30. Hata T, Rajabi H, Takahashi H, et al. MUC1-C activates the NuRD complex to drive dedifferentiation of triple-negative breast cancer cells. Cancer Res 2019;79:5711-22.
31. Luan Z, Morimoto Y, Fushimi A, et al. MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas. Carcinogenesis 2022;43:67-76.
33. Bhatia S, Wang P, Toh A, Thompson EW. New insights into the role of phenotypic plasticity and emt in driving cancer progression. Front Mol Biosci 2020;7:71.
34. Ahmad R, Raina D, Trivedi V, et al. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat Cell Biol 2007;9:1419-27.
35. Ahmad R, Raina D, Joshi MD, et al. MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res 2009;69:7013-21.
36. Ahmad R, Rajabi H, Kosugi M, et al. MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal 2011;4:ra9.
37. Gnemmi V, Bouillez A, Gaudelot K, et al. MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter. Cancer Lett 2014;346:225-36.
38. Alam M, Bouillez A, Tagde A, et al. MUC1-C represses the crumbs complex polarity factor CRB3 and downregulates the hippo pathway. Mol Cancer Res 2016;14:1266-76.
39. Tam WL, Weinberg RA. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med 2013;19:1438-49.
40. Skrypek N, Goossens S, De Smedt E, Vandamme N, Berx G. Epithelial-to-mesenchymal transition: epigenetic reprogramming driving cellular plasticity. Trends Genet 2017;33:943-59.
41. Wainwright EN, Scaffidi P. Epigenetics and cancer stem cells: unleashing, hijacking, and restricting cellular plasticity. Trends Cancer 2017;3:372-86.
42. Rajabi H, Tagde A, Alam M, et al. DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells. Oncogene 2016;35:6439-45.
43. Hiraki M, Maeda T, Bouillez A, et al. MUC1-C activates BMI1 in human cancer cells. Oncogene 2017;36:2791-801.
44. Yamamoto M, Bharti A, Li Y, Kufe D. Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion. J Biol Chem 1997;272:12492-4.
45. Rajabi H, Ahmad R, Jin C, et al. MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem 2012;287:10703-13.
46. Bouillez A, Rajabi H, Pitroda S, et al. Inhibition of MUC1-C suppresses MYC expression and attenuates malignant growth in KRAS mutant lung adenocarcinomas. Cancer Res 2016;76:1538-48.
47. Tagde A, Rajabi H, Bouillez A, et al. MUC1-C drives MYC in multiple myeloma. Blood 2016;127:2587-97.
48. Clapier CR, Iwasa J, Cairns BR, Peterson CL. Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes. Nat Rev Mol Cell Biol 2017;18:407-22.
49. Bracken AP, Brien GL, Verrijzer CP. Dangerous liaisons: interplay between SWI/SNF, NuRD, and polycomb in chromatin regulation and cancer. Genes Dev 2019;33:936-59.
50. Piunti A, Shilatifard A. The roles of polycomb repressive complexes in mammalian development and cancer. Nat Rev Mol Cell Biol 2021;22:326-45.
51. Rajabi H, Hiraki M, Tagde A, et al. MUC1-C activates EZH2 expression and function in human cancer cells. Sci Rep 2017;7:7481.
52. Hagiwara M, Yasumizu Y, Yamashita N, et al. MUC1-C activates the BAF (mSWI/SNF) complex in prostate cancer stem cells. Cancer Res 2021;81:1111-22.
53. Cenik BK, Shilatifard A. COMPASS and SWI/SNF complexes in development and disease. Nat Rev Genet 2021;22:38-58.
54. Hata T, Rajabi H, Yamamoto M, et al. Targeting MUC1-C inhibits TWIST1 signaling in triple-negative breast cancer. Mol Cancer Ther 2019;18:1744-54.
55. Bekkering S, Domínguez-Andrés J, Joosten LAB, Riksen NP, Netea MG. Trained immunity: reprogramming innate immunity in health and disease. Annu Rev Immunol 2021;39:667-93.
56. Hagiwara M, Fushimi A, Yamashita N, et al. MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells. Oncogene 2021;40:4930-40.
57. Bhattacharya A, Fushimi A, Yamashita N, et al. MUC1-C Dictates JUN and BAF-mediated chromatin remodeling at enhancer signatures in cancer stem Cells. Mol Cancer Res 2022; doi: 10.1158/1541-7786.MCR-21-0672.
58. Hodges C, Kirkland JG, Crabtree GR. The many roles of BAF (mSWI/SNF) and PBAF complexes in cancer. Cold Spring Harb Perspect Med 2016;6:a026930.
59. Hopson S, Thompson MJ. BAF180: Its Roles in DNA repair and consequences in cancer. ACS Chem Biol 2017;12:2482-90.
60. Porter EG, Dhiman A, Chowdhury B, et al. PBRM1 regulates stress response in epithelial cells. iScience 2019;15:196-210.
62. Deng W, Jacobson EC, Collier AJ, Plath K. The transcription factor code in iPSC reprogramming. Curr Opin Genet Dev 2021;70:89-96.
63. Singhal N, Graumann J, Wu G, et al. Chromatin-remodeling components of the baf complex facilitate reprogramming. Cell 2010;141:943-55.
64. Chronis C, Fiziev P, Papp B, et al. Cooperative binding of transcription factors orchestrates reprogramming. Cell 2017;168:442-459.e20.
65. Chen K, Long Q, Xing G, et al. Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO J 2020;39:e99165.
66. King HW, Klose RJ. The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells. Elife 2017;6:e22631.
67. Iurlaro M, Stadler MB, Masoni F, et al. Mammalian SWI/SNF continuously restores local accessibility to chromatin. Nat Genet 2021;53:279-87.
68. Marino MM, Rega C, Russo R, et al. Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF. J Biol Chem 2019;294:861-73.
69. Valletta M, Russo R, Baglivo I, et al. Exploring the interaction between the SWI/SNF chromatin remodeling complex and the Zinc finger factor CTCF. Int J Mol Sci 2020;21:E8950.
70. Vierbuchen T, Ling E, Cowley CJ, et al. AP-1 transcription factors and the BAF complex mediate signal-dependent enhancer selection. Mol Cell 2017;68:1067-1082.e12.
71. Angelis ML, Francescangeli F, La Torre F, Zeuner A. Stem cell plasticity and dormancy in the development of cancer therapy resistance. Front Oncol 2019;9:626.
72. Miranda A, Hamilton PT, Zhang AW, et al. Cancer stemness, intratumoral heterogeneity, and immune response across cancers. Proc Natl Acad Sci U S A 2019;116:9020-9.
73. Malta TM, Sokolov A, Gentles AJ, et al. Cancer genome atlas research network. machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell 2018;173:338-354.e15.
74. Quintanal-Villalonga Á, Chan JM, Yu HA, et al. Lineage plasticity in cancer: a shared pathway of therapeutic resistance. Nat Rev Clin Oncol 2020;17:360-71.
75. Hagiwara M, Fushimi A, Bhattacharya A, et al. MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer. Oncoimmunology 2022;11:2029298.