Volume 4, Issue 2 (2024) – 10 articles
Cover Picture: The study investigates the risk ratios for major adverse foot events (MAFEs) and the presence of functional mobility deficits in participants with diabetic peripheral neuropathy (DPN) across stages of chronic kidney disease (CKD). The research involved 284 participants with diabetes mellitus, peripheral neuropathy, and CKD. MAFEs, including foot fractures, ulcerations, Charcot neuropathic arthropathy (CN), osteomyelitis, and minor foot amputations, were collected from medical records, while functional mobility deficits were assessed using the modified physical performance test (mPPT). The study found consistent risk ratios for neuropathic foot fracture, CN, and diabetic foot ulceration across CKD stages. However, the risk of minor amputation increased in stages 4 and 5 CKD. Additionally, the risk of moderate or severe mobility deficit increased in stages 3, 4, and 5 CKD. The study highlights the increased risks of MAFEs and functional mobility deficits as CKD and DPN progress, emphasizing the importance of early recognition and patient education to prevent adverse outcomes. The findings underscore the need for healthcare providers to closely monitor DPN and CKD stages and take appropriate preventive measures. However, the study acknowledges several limitations, including data collection methods, cohort study design, and the absence of comprehensive data on other diabetic complications and concurrent impairments. Further research is needed to understand the time sequence of MAFE occurrence and evaluate preventive interventions across CKD stages.
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