Topic: Recent Advances in Organoid, Organ-on-chip and Microphysiological Systems

A powerful in vitro model plays an essential role in speeding up drug development and the lack of such models can hamper the discovery of drugs for critical diseases. Advanced in vitro models, such as organoids, organ-on-chip systems, and microphysiological systems, are gaining increasing popularity in the realm of drug discovery. Conventional in vitro models, including cell lines, primary cells, and ex vivo human tissues, hold inherent drawbacks. Accumulating evidence indicates that cell lines are vulnerable to mutations over prolonged culture periods, potentially leading to inconsistent results across different labs using the same cell line. Furthermore, in vitro models containing single cell types fall short of mimicking the complexity of in vivo organs and tissues that are typically composed of multiple cell types. Ethical considerations and resource constraints make it difficult to use human tissues as ex vivo models. Organoids are three-dimensional models harboring organ-like structures comprising various cell types derived from a renewable stem cell source. The organ-on-a-chip model is based on microfluidic devices built using a combination of cell biology, engineering, and biomaterial technology. The microenvironment of the chip mimics that of the organ in terms of tissue interfaces, fluid flow, and mechanical stimulation. These complicated models are considered to be more translatable to in vivo physiology compared to traditional in vitro models including cell line and primary cells. Thus, Organoids, organ-on-chip systems, and microphysiological systems are promising in vitro models for drug discovery. As such, we extend an invitation for valuable contributions that align with the One Health concept. Research articles related to advanced in vitro models, organoids, organ-on-chip models, and microphysiological systems within our topic are all welcome.

We welcome submissions on the selected topics and beyond. The Special Issue covers the following topics, relevant but not limited to:
1. Establishment of new organoid, organ-on-chip, and other three-dimensional models;

2. Gene manipulation within organoid, organ-on-chip, and other three-dimensional models;

3. Disease modeling employing organoid, organ-on-chip, and other three-dimensional models;

4. Drug screening using organoid, organ-on-chip, and other three-dimensional models;

5. Personalized medicine leveraging organ-on-chip and other three-dimensional models;

6. Regeneration and development studies using organ-on-chip and other three-dimensional models;

7. Transcriptomics, proteomics, and other omics studies utilizing organ-on-chip and other three-dimensional models;

8. Mechanistic studies using organ-on-chip and other three-dimensional models.

Organoid, organ-on-chip, MPS, in vitro model, 3D model

1 Sep 2024