Topic: Advances of Genomic Alterations in Oral Cancer

This Special Issue focuses on recent discoveries and advancements in genomic alterations underlying the initiation, progression, and therapeutic response of oral cancer. By integrating multi-omics approaches, including genomics, epigenomics, and transcriptomics, we aim to refine the molecular characterization of oral cancer, identify novel diagnostic and prognostic biomarkers, and explore precision oncology strategies.

We invite submissions in various formats, including Original Articles, Reviews, Meta-Analyses, Systematic Reviews, Technical Notes, Commentaries, Editorials, Letters to the Editor, Opinions, and Perspectives, covering but not limited to the following topics:

● Comprehensive genomic and transcriptomic profiling of oral cancer;

● Somatic mutations, copy number variations, and structural variations in oral squamous cell carcinoma;

● Epigenetic modifications and their role in oral carcinogenesis;

● Molecular signatures for early detection, risk stratification, and therapeutic response prediction;

● The impact of HPV and other oncogenic viruses on the oral cancer genome;

● Genomic landscape of oral potentially malignant disorders and malignant transformation;

● Targeting dysregulated signaling pathways in oral cancer treatment;

● Genomic determinants of perineural invasion, bone invasion, and metastasis in oral cancer;

● Tumor microenvironment interactions and immunogenomic alterations in oral cancer;

● Clinical and translational applications of genomic discoveries in precision oral oncology.