Topic: Tumor Heterogeneity as a Driver of Drug Resistance: Implications for Personalized Therapeutic Strategies

Tumor heterogeneity presents a significant challenge in cancer treatment, contributing to the emergence of drug resistance and therapy failure. Genetic, epigenetic, and microenvironmental variations within tumors enable subpopulations of cancer cells to evade treatment, adapt to therapeutic pressure, and drive disease progression. Understanding the mechanisms by which heterogeneity influences resistance is critical for developing personalized therapeutic strategies that can effectively target diverse tumor populations. This Special Issue aims to explore the latest advancements in decoding tumor heterogeneity and its role in drug resistance, with a focus on innovative approaches to precision medicine. We welcome studies that investigate resistance mechanisms, identify novel therapeutic targets, and propose strategies for overcoming treatment barriers through personalized approaches.

The topics covered include, but are not limited to:

1. Genetic and epigenetic mechanisms of resistance in heterogeneous tumors;

2. Single-cell and spatial profiling of resistance pathways;

3. Targeted therapy resistance in heterogeneous tumors;

4. Personalized therapeutic strategies to overcome resistance;

     etc.