fig6

Figure 6. (A) Inflammatory microenvironment triggers hydrogel destruction and IFX releasing. AL/HA@IFX promot epithelial barrier reparation and modulating of gut flora^[106]. Copyright 2023, Elsevier; (B) Schematic illustration of orally administrated IMT/SD-hydrogel at colon with intestine enzyme triggered release through epithelial adherens junctions for enhanced therapeutic efficiency^[107]. Copyright 2022, Springer; (C) Schematic of the in vivo neural stimulation experiment with a MECH microelectrode^[129]. Copyright 2019, Springer Nature; (D) Device and its various components^[130]. Copyright 2021, Springer Nature; (E) Schematic illustration of chronic neuromodulation application with photopatternable MH to achieve robust electrical integration between implanted bioelectronics and peripheral nerves^[131]. Copyright 2023, ACS Publications. IFX: Infliximab; AL/HA: an colon microenvironment-responsive; IMT/SD: imatinib and sodium deoxycholate; MECH: a micropatterned electrically conductive hydrogels.