fig4

Figure 4. (A) HM-HPMC/α-CD rapidly forms a gel on the ocular surface, enhancing the ocular absorption of the drug^[97]. Copyright 2019, RSC Publishing; (B) Drug release in different formulated hydrogels^[98]. Copyright 2017, ACS Publications; (C) Hydrogels using model drugs play a dual role in treating periodontitis and antibacterial disease^[11]. Copyright 2019, Elsevier; (D) The preparation and application of the CS/β-GP/gelatin hydrogels^[99]. Copyright 2019, Elsevier; (E) Cumulative drug release after repeated MMP-9 exposure (↓) of the PEG hydrogels cross-linked with MMP-sensitive linker B. N = 3^[101]. Copyright 2023, Elsevier; (F) Intradermal Injection of a Thermoresponsive Polymeric Dexamethasone Prodrug (ProGel-Dex) Ameliorate Dermatitis in an IMQ-Induced Psoriasis-like Mouse Model^[100]. Copyright 2024, ACS Publications. HM-HPMC/α-CD: Hydrophobically modified hydroxypropyl methylcellulose/α-cyclodextrin; CS/β-GP: chitosan/β-sodium glycerophosphate; MMP-9: matrix metalloproteinase-9; PEG: polyethylene glycol; IMQ: imiquimod.