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Figure 10. LIG-based biochemical skin electronics with single sensing mode for intelligent healthcare. (A) Optical photograph of pH sensor under longitudinal strain; (B) Outputs of a pH sensor responding to different transverse strains. Reproduced with permission^[41]. Copyright 2017, American Chemical Society; (C) An electrochemical dopamine sensor based on PEDOT-modified LIG; (D) Response of electrochemical dopamine sensor to different concentrations of dopamine. Reproduced with permission^[75]. Copyright 2018, Elsevier B.V.; (E) Illustration of a packaged wearable non-enzymatic glucose sensor; (F) Experimental results of the glucose sensor, responding to human sweats at different time points. Reproduced with permission^[40]. Copyright 2021, Elsevier B.V.; (G) Schematic of wearable FeNCs/LIG-based electrochemical patch for sweat metabolites monitoring; (H) Tyr concentrations evaluated by developed electrochemical patch and LC-MS. Reproduced with permission^[103]. Copyright 2024, Elsevier B.V.; (I) A soft electrochemical sensing patch for cortisol detection; (J) Cortisol monitoring from three physically untrained volunteers (B1, B2, B3) and one trained volunteer (B4) in a cycling exercise. Reproduced with permission^[43]. Copyright 2020, Cell Press; (K) Schematic illustration exhibits the use of NOx gas as a promising biomarker for representative human diseases; (L) Response of the gas sensor to human exhaled breath samples from different subjects, including patients (with respiratory diseases) and healthy volunteers. Reproduced with permission^[39]. Copyright 2022, Springer Nature. LIG: Laser-induced-graphene; PEDOT: poly(3,4-ethylenedioxythiophene); FeNCs: iron nano-catalysts; Tyr: tyrosine; LC-MS: liquid chromatography-mass spectrometry.