fig3
Figure 3. Evaluation of ICH-based soft brain interface. (A) Fabrication scheme of ICH-based soft brain interface. Each step represents: (i) reforming PVDF-HFP film, (ii) punching channel site, (iii, iv) extrusion-based printing of ICH, and (v) connecting wires to ICH arrays; (B) Photograph of ICH-based soft brain interface; (C) Evaluating tensile stress per strain of “with” or “without” ICH-injected on the PVDF-HFP; (D) Young’s modulus of “with” or “without” ICH-injected PVDF-HFP and previous reported Young’s modulus of “PDMS” and “SEBS”; (E) Photograph of conformal contact between ICH-based soft brain interface with brain phantom model; (F) Electrochemical impedance property of different pair of channels (long connection wire from channel “1, 3” and short connection wire from channel “2, 4”) from ICH-based soft brain interface in PBS solution; (G-I) representative live/dead staining images of HT22 cells of NT (G), PVDF-HFP (H), and ICH (I) after 24 h incubation at 37°C. Living cells appear green, dead cells appear red (scale bar = 400
