fig1

Figure 1. Alternative spliced variants of CEACAM1. In the liver, CEACAM1 is expressed as 2 spliced isoforms resulting from deletion or inclusion of Exon 7. The long isoform, denoted CC1-4L, contains a longer intracellular tail than the short (CC1-4S) (71 vs. 11 a.a.). Its cytoplasmic tail includes serine and tyrosine phosphorylation sites. Serine503 residue must be intact for Tyrosine488 to undergo phosphorylation by the insulin receptor tyrosine kinase. Both forms have 4 IgG loops and several CHO on their extracellular domains. CEACAM1: Carcinoembryonic antigen-related cell adhesion molecule 1; CEACAM1-4L: CC1-4L; CHO: carbohydrate chains.