fig5

Onion-skin type of periductular sclerosis in mice with genetic deletion of biliary kindlin-2 as tight junction stabilizer: a pilot experiment indicating a primary sclerosing cholangitis (PSC) phenotype

Figure 5. Sirius red staining of liver sections from 8-week tamoxifen-induced control (A) and kindlin-2-deleted (B) mice. The control mice displayed normal bile ducts, while the kindlin-2-deleted mice exhibited a characteristic onion-skin type of fibrosis around the bile ducts. Space bars are 250 µm. BD: Bile duct; PA: portal artery; PV: portal vein.

Metabolism and Target Organ Damage
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