fig5

Figure 5. Circular dendrograms display common loci for MASLD and CMTs. Within the inner circle, independent variants shared among MASLD-CMTs trait pairs are shown, with 73 shared causal variants highlighted by asterisks [posterior probability of H4 (PP.H4) > 0.7]. Annovar-inferred genes for the shared variants are depicted in the outer circle. Genes are color-coded to signify their overlap with the four gene recognition methodologies: TWAS, SMR, GCTA-fastBAT, and MAGMA. Gray denotes genes not identified by any approach; black indicates those identified by at least one method, and red represents genes identified by all four methods. MASLD: Metabolic dysfunction-associated steatotic liver disease; CMTs: cardiometabolic traits; TWAS: transcriptome-wide association study; SMR: Summary-data-based Mendelian Randomization; AAA: abdominal aortic aneurysm; WHRadjBMI: WHR adjusted for BMI; WHR: waist-to-hip ratio; BMI: body mass index; T2D: type 2 diabetes; VTE: venous thromboembolism; TG: triglyceride; nonHDLC: non-HDL cholesterol; MI: myocardial infarction; HyperT: hypertension; CAD: coronary artery disease; HF: heart failure; PAD: peripheral artery disease; AF: atrial fibrillation; FI: fasting insulin.