fig3

Figure 3. The general overview of the pleiotropic links between MASLD and CMTs. (A) Count of shared SNPs between MASLD and CMTs using MTAG and CPASSOC; (B) HyPrColoc identified five causal variants that are common across multiple traits; (C) LocusZoom visualizations of rs429358 causal variant for MASLD and three CMTs, including T2D, WHR, and WHRadjBMI. The X-axis displays the chromosomal locations of SNPs, and the Y-axis represents the negative base 10 logarithm of P-values [-log₁₀(p)] from two-sided statistical analyses. MASLD: Metabolic dysfunction-associated steatotic liver disease; CMTs: cardiometabolic traits; T2D: type 2 diabetes; WHR: waist-to-hip ratio; WHRadjBMI: WHR adjusted for BMI; MTAG: multi-trait analysis of GWAS; CPASSOC: cross-phenotype association test; SNPs: single nucleotide polymorphisms; BMI: body mass index; VTE: venous thromboembolism; TG: triglyceride; nonHDLC: non-HDL cholesterol; MI: myocardial infarction; HyperT: hypertension; CAD: coronary artery disease; HF: heart failure; PAD: peripheral artery disease; AF: atrial fibrillation; FI: fasting insulin; AAA: abdominal aortic aneurysm; DBP: diastolic blood pressure.