fig2
Figure 2. Genetic correlation and causal relationship between MASLD and CMTs. (A) The genetic correlation (rg) derived from LDSC was displayed on this heatmap, using colors to show the correlation’s strength, *P < 0.05; **FDR < 0.05; (B) Causal relationships were inferred using two-sample MR employing five distinct methods. MR-APSS validated causalities and labeled them using the purple font. Dots illustrate the OR, and the color bars represent the 95% confidence intervals. MASLD: Metabolic dysfunction-associated steatotic liver disease; CMTs: cardiometabolic traits; LDSC: linkage disequilibrium score regression; FDR: false discovery rate; MR: Mendelian Randomization; OR: odds ratios; rg: genetic correlation.
