fig2
Figure 2. A novel hypothesis on the pathogenesis of PSC. In cases of TJ disruption, the availability of PC interacting with mucin-2 and mucin-3 within the mucus of the biliary channels is reduced. Insufficient PC reduces mucus hydrophobicity and mucus barrier function, exposing biliary cells to the toxic effects of biliary acids. Figure created with BioRender.com. PSC: Primary sclerosing cholangitis; TJ: tight junctions; PC: phosphatidylcholine.
