fig2

Figure 2. Multi-lineage liver organoids models such as hiPSC-derived 3D hepatic organoids-macrophages model, Hepatobiliary organoids, liver organoids incorporating a perfusable vascular network, and Organ-on-Chip Platform, for investigating MASLD progression. ESCs: Embryonic stem cells; hiPSC: human induced pluripotent stem cells; ipreMPs: human induced pluripotent stem cell-derived pre-macrophages; MASLD: metabolic dysfunction-associated steatotic liver disease; NASH: non-alcoholic steatohepatitis; rOoC Platform: Organ-on-Chip platform; PHs: primary hepatocytes; PPs: pancreatic progenitor cells; SC-islet: human induced pluripotent stem cell-derived pancreatic islet-like spheroid.