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Figure 1. Hepatocyte organoids originated from Lgr5+ stem cells, PLC, human pluripotent stem cells, human induced pluripotent stem cells, and human chemically-derived hepatic progenitors for investigating MASLD progression. MASLD: Metabolic dysfunction-associated steatotic liver disease; NASH: non-alcoholic steatohepatitis; PSCs: pluripotent stem cells; ESCs: embryonic stem cells; hiPSC: human-induced pluripotent stem cells; PLC: primary liver cells; HUVECs: human umbilical vein endothelial cells.