fig2
![Sex differences in glutathione metabolism and acetaminophen toxicity](https://image.oaes.cc/2464509c-ddd1-43af-b136-220aae4ad121/mtod3044.fig.2.jpg)
Figure 2. Consequences of the GSH regulatory motif. Panel B shows the GSH regulatory motif (taken from Figure 1), including the effects of estradiol and the inhibition of GCL and glutathione synthetase (GS) by GSH. Panel A shows the steady state value of GSH as a function of the parameter S, which increases with estradiol concentration and is defined in formula (2). The GSH curve goes up for low estradiol values, reaches a peak and descends for high estradiol values. The reasons for this behavior are discussed in the text.