fig2

Figure 2. Consequences of the GSH regulatory motif. Panel B shows the GSH regulatory motif (taken from Figure 1), including the effects of estradiol and the inhibition of GCL and glutathione synthetase (GS) by GSH. Panel A shows the steady state value of GSH as a function of the parameter S, which increases with estradiol concentration and is defined in formula (2). The GSH curve goes up for low estradiol values, reaches a peak and descends for high estradiol values. The reasons for this behavior are discussed in the text.