fig1

Figure 1. Algorithm to manage NAFLD based on the stratification of the risk of liver-related and CVD complications. The algorithm integrates noninvasive serum biomarkers of liver fibrosis (e.g., NFS, FIB-4, HFS) and sonoelastographic techniques (VCTE, SWE, or MRE) to stratify the risk fibrosis and, as suggested by recent data, the risk of CVD to manage the treatment and follow-up of NAFLD. CAP: Controlled attenuation parameter; CVD: cardiovascular disease; FIB-4: fibrosis-4; HFS: hepamet fibrosis score; LSM: liver stiffness measurement; MRE: magnetic resonance elastography; NAFLD, nonalcoholic fatty liver disease; NFS: NAFLD fibrosis score; SWE: point shear wave elastography; US: ultrasonography; US-FLI: ultrasonographic fatty liver indicator; VCTE: vibration-controlled transient elastography.