fig8

Figure 8. Analysis of gene contribution to melting points for (A-C) spacers and (D-F) substituents. The frequency of occurrence of each spacer (A) and substituent (D) in preferred structures is represented numerically in the sectors of the Nightingale rose diagram. The CDF curves are given for spacers (B) and substituents (E). The integrated area enclosed by the CDF curve of each spacer (C) and substituent (F) and the average CDF curve was represented as a histogram to describe the impact of the chemical unit on the melting point. CDF: Cumulative distribution function.