fig4
From: The NOAEL equivalent for the cumulative body burden of cadmium: focus on proteinuria as an endpoint
Figure 4. BMDL5 values of ECd/Ccr for proteinuria and low eGFR. Bootstrap model weighting and averaging of BMDL and BMDU bounds of the 95%CI of BMD for (A-C) 5% prevalence of protinuria and (D-F) 5% prevalence of low eGFR. BMDL and BMDU values of ECd/Ccr were based on two-stage, logarithmic logistic, Weibull, logarithmic probability, gamma, exponential and Hill dose-response models. BMDL: Benchmark dose lower; eGFR: estimated glomerular filtration rate; BMDU: benchmark dose upper; CI: confidence interval.