fig1
From: Role of plasminogen activator inhibitor-1 (PAI-1) in age-related cardiovascular pathophysiology
Figure 1. The role of PAI-1 in vascular stiffness and senescence amplification. (A) PAI-1 inhibits degradation of the ECM via inhibiting the tPA/uPA-mediated cleavage of metalloproteinases. (B) PAI-1 inhibits eNOS, reducing NO bioavailability and promoting vascular stiffness in the endothelium. (C) PAI-1 amplifies senescence by increasing SASP factors (IL-6, IL-8, TGF-β, CXCL2), which exacerbate vascular dysfunction and aging.
