fig2
From: Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies
Figure 2. Mechanisms by which cellular senescence contributes to vascular dysfunction. Excess senescent cell and senescence-associated secretory phenotype (SASP) burden drive macro-mechanistic processes including reactive oxygen species (ROS)-related oxidative stress, chronic inflammation, and reduced nitric oxide (NO) bioavailability. In turn, these fundamental aging processes promote other established and putative underlying mechanisms that contribute to vascular dysfunction. ECM: Extracellular matrix; ER: endoplasmic reticulum.
