fig1
Figure 1. Schematic of findings of Zhou et al.[16]. H2S-stimulated M2 macrophages produce EVs that have increased ability to promote differentiation of MSCs into osteoblasts in vitro. When H2S-stimulated EVs were incorporated into Matrigel along with MSCs, which was then used to fill calvarial critical-size defects in mice, bone regeneration occurred significantly more quickly than when unstimulated M2 macrophage EVs or no EVs were used with MSCs. H2S: Hydrogen sulfide; EVs: extracellular vesicles; MSCs: mesenchymal stem cells.
