scheme2

Asymmetric [4+2] annulation of <i>N</i>-sulfonyl ketimines: access to <i>N</i>-heterocycles bearing 1,3-nonadjacent stereocenters with a quaternary carbon center

Scheme 2. Substrate scope of cyclic N-sulfonyl ketimines 1a. aConditions: 1 (0.10 mmol), 2a (0.15 mmol), and catalyst (0.01 mmol) in CHCl3(1.0 mL) at 25 °C; bIsolated yield; cDetermined by 1H NMR of the crude reaction mixture; dThe ee values were determined by chiral HPLC analysis.

Chemical Synthesis
ISSN 2769-5247 (Online)

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