scheme2

Enantioselective synthesis of 6-(Indole-2-yl)-3,4-dihydropyran-2-one skeletons by <i>N</i>-Heterocyclic carbene-catalyzed asymmetric [3 + 3] cycloaddition of α-bromocinnamaldehyde

Scheme 2. Substrates scope. Reaction conditions: pre-cat. A (20 mol%), NaHCO3 (1.5 equiv), 1 (0.1 mmol), and 2 (0.12 mmol) in THF (1.5 mL).

Chemical Synthesis
ISSN 2769-5247 (Online)

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