fig6

Figure 6. JQ1 + CDC25i or JQ1 + gemcitabine is synergistic in gemcitabine-resistant Panc1.gemR cells. (A and B) Fa-CI plot and CI table. CIs were calculated using compuSyn to determine whether JQ1 + CDC25i was antagonistic, additive, or synergistic. The CI < 0.5 indicates strong synergy; (C) Fa-CI plot and CI table to determine whether JQ1 + gemcitabine was synergistic in Panc1.gemR cells. The CI < 0.7 indicates synergy. CI = 1, 1 represents additive, synergistic, or antagonistic effects, respectively. CDC25i: CDC25 inhibitor; gemR: gemcitabine-resistant; Fa: Fraction affected; CI: combination index.