fig5

Figure 5. JQ1 + CDC25i decreases IC₅₀s in Panc1 and gemcitabine-resistant Panc1.gemR cells. (A) IB data showing that Panc1.gemR cells express a higher level of CDC25B than parent Panc1 cells; (B) Sensitivity of Panc1 and (C) Panc1.gemR cells to JQ1 + CDC25i. Cells were exposed to JQ1, CDC25i, or JQ1 + CDC25i for 96 h and cell viability assessed using alamarBlue assays. IC₅₀ values for JQ1, CDC25Bi, and the combination are shown in the right panel. N = 3. CDC25i: CDC25 inhibitor; gemR: gemcitabine-resistant; IB: immunoblot; CDC25B: cell division cycle 25B.