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Figure 4. CDC25B-high pancreatic cancer cells are more sensitive to the BETi JQ1 than CDC25B-low cells. (A) IB showing the expression levels of CDC25B in Panc1, BxPC3, and MIA PaCa-2 pancreatic cancer cell lines; (B) A bar graph showing the quantitation of data in panel A. Quantitation was done using ImageJ. N = 3; (C) JQ1 sensitivity was assessed using alamarBlue cell viability assays after 72-hour exposure to JQ1. Data are presented as the mean ± SD. N = 3; (D) The table shows the IC₅₀ values of each cell line. CDC25B: Cell division cycle 25B; BETi: bromodomain and extraterminal domain inhibitor; IB: immunoblot.