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Figure 4. NETs act as a driver of carcinogenesis and can promote tumor growth. (A) NETs induce checkpoint blockade and replication errors in colon epithelial cells, leading to the onset of colorectal cancer; (B) The formation of clots by NETs with platelets reduces neutrophils’ function and induces their transformation to N2 phenotype; (C) MMP-9 acts on endothelial cells, promoting the secretion of VEGF, thereby further enhancing tumor growth. Created with BioRender.com (accessed on 30 June 2022). NETs: Neutrophils extracellular traps; MMP-9: matrix metalloproteinases-9; VEGF: vascular endothelial growth factors.