fig2

Figure 2. The schematic diagrams of three types of NETosis: Suicidal NETosis, Vital NETosis, and Mitochondrial NETosis. (I) Suicidal NETosis: Activated neutrophils undergo membrane rupture, releasing nuclear DNA and proteins into the extracellular space. The entire process takes several hours to complete, and following completion, the neutrophil undergoes cell death; (II) Vital NETosis: Activated neutrophils release nuclear DNA and proteins into the extracellular space through vesicular transport, completing the entire process within 10-60 min. Neutrophils remain viable after completing this process; (III) Mitochondrial NETosis: Activated neutrophils release mitochondrial DNA and proteins into the extracellular space, completing the entire process in only 15-20 min, with the neutrophils maintaining cellular viability after the process. Created with BioRender.com (accessed on 30 June 2022). NET: Neutrophils extracellular trap; DNA: deoxyribonucleic acid.