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Figure 4. Comparative analysis of gene co-mutation patterns in NSCLC patients carrying or not BRAF mutations. (A and B) Matrix-like heatmap (oncoprint) of gene mutations (cutoff 5%) indicating co-occurring or mutual exclusivity mutational patterns in BRAF-mutant NSCLC patients of cohort #1 (A) and cohort #2 (B); (C and D) Bar plot of the number of BRAF-mutant NSCLC patients of cohort #1 (C) and cohort #2 (D) with mutational overlap. The spots under the bar plot show the presence of mutually exclusive or co-occurrence mutations (highlighted in blue and red, respectively). On the right, for each mutated gene, the table indicates the association parameters and statistical significance; (E and F) OS in NSCLC patients carrying BRAF mutation alone (green) or co-occurrence of (E) SMARCA4 (orange) or (F) STK11 (blue) mutations, on Kaplan-Meier graphs; (G-I) Box plots showing Winter (G), Ragnum (H), and Buffa (I) hypoxia scores in NSCLC patients carrying BRAF mutation alone or co-occurrent with the p53 gene. NSCLC: Non-small cell lung carcinoma; OS: overall survival.